Sinclair Research Blog

AALAS 72nd Annual Meeting

AALAS 72nd Annual Meeting


by Sinclair Research


Come visit us in person at Booth #1413!

Sinclair Bio Resources is a state-of-the art miniature swine production facility that supports the biomedical research community by providing quality miniature swine, animal model development and bioproducts and has contributed to the development of large animal models, and is the only private company primarily involved in large animal model development.


Meet our scientific experts at our AALAS Seminar!

Problem Solving 101: Breaking Roadblocks to Success for Miniature Swine Users
Wednesday, October 20, 2021 8:00am - 10:15am

Featuring Sinclair Bio Resources’ Derek Brocksmith; founder and CEO Guy Bouchard; Medical University of South Carolina Professor Emeritus M. Michael Swindle; and Sinclair Research’s Sr. Vice President of Research, Dr. Scott Boley; this seminar will examine the growing presence of miniature swine in biomedical research. Problem solving including best practices for surgical modeling, and selecting the right miniature swine age and type will be highlighted, as well as miniature swine applications in toxicology, pharmacology, and training resources. Participants will gain knowledge on the technical aspects and practices related to anesthesia, peri/post-op complications, handling, and model selection for study conduct, including proper selection of anesthetics and analgesics, behavior training for ease of handling, translational aspects, and selection of relevant lineages.


M. Michael Swindle, D.V.M. is Professor Emeritus since he retired in 2013 as Director, Division of Laboratory Animal Resources and Professor & Chairman in the Department of Comparative Medicine at the Medical University of South Carolina. He was employed at MUSC since 1985.

Dr. Swindle is a Diplomate of the American College of Laboratory Animal Medicine (1982) and has more than 300 scientific publications and oral presentations to his credit. He is the recipient of research awards from the American Heart Association, the Academy of Surgical Research, the American Association for Laboratory Animal Science, the American Society of Laboratory Animal Practitioners and the American College of Laboratory Animal Medicine.

scott_boley_150x150Dr. Scott E. Boley, PhD, DABT, has advised Sponsors on their nonclinical needs for the last 15 years and managed toxicology programs for 19 years. He has extensive expertise in drug development as well as the regulatory expectations for a variety of test article types and indications. In his role as Senior Vice President of Research, Scott oversees the Research, Report Services, and SEND groups at Sinclair Research that supports each Sponsor’s nonclinical safety programs. Scott is a diplomate of the American Board of Toxicology and holds a B.Sc. in Biochemistry and a Ph.D. in Biochemistry/Environmental Toxicology from Michigan State University.
Guy BouchardDr. Guy Bouchard, DVM, MS, DACT, is the founder and CEO of Sinclair Research. Board certified by the American College of Veterinary Theriogenologists, he has more than 35 years of experience in research with laboratory animals and is an expert in drug development and conducting preclinical evaluations of small and large molecule therapeutics. Dr. Bouchard earned a DVM in Veterinary Medicine from the University of Montreal, MSc in Animal Reproduction and Comparative and Laboratory Animal Medicine from the University of Missouri-Columbia.
Derek Brocksmith General Manager Sinclair BioResourcesDerek Brocksmith is the General Manager of Sinclair Bio Resources and has spent 13 years managing the largest production herds of minipigs for biomedical research in North America. Previous to joining Sinclair, Derek spent most of his career working in agriculture and agriculture-related fields with a focus on swine production. Derek earned bachelor’s degrees in animal science and criminal justice from National University in San Diego while serving in the United States Marine Crops.

Also, don’t miss the latest scientific content from Sinclair Bio Resources!

Platform Presentations:

Extending the Use of Exposed Vascular Access Ports in Miniature Swine 
By Dr. Emily Callahan, DVM 
Wednesday, October 20, 2021 3:45pm - 4:00pm

Jugular vein vascular access ports (VAPs) are commonly implanted to allow for repeated intravenous access in miniature swine. The purpose of this study was to determine the efficacy of relocating exposed VAPs to a new subcutaneous (SC) position in castrated male, miniature swine to allow continuation on study.

Development of Long-term Cecal Catheterization for Repeated Infusions in Miniature Swine 
By Dr. Emily Callahan, DVM 
Thursday, October 21, 2021 10:00am - 10:15am

Implantation of infusion catheters in the small intestines has been described in multiple species. Common sites include the duodenum, jejunum, and ileum, but there is limited literature on catheter placement in the cecum or large intestines of swine. The purpose of this study was to develop a surgical method to allow liquid drug delivery directly to the cecum and bypass the stomach and small intestines, while allowing repeated, sedation-free dosing.

About the presenter:
Emily Callahan, DVM, joined Sinclair in December 2018. She is a 2014 graduate of the University of Missouri’s College of Veterinary Medicine. She worked as a clinical veterinarian in private small animal practice until joining Sinclair Research.


White Paper:

Preventing Complications in the Perioperative Period in Porcine Surgery
By Dr. Michael Swindle, DVM  

Many of the models for which swine have been developed involve anesthesia and surgery. Complications due to the physiologic effects of anesthetic and analgesic protocols are a significant factor in mortality and other physiologic complications in porcine research models. Inappropriate surgical technique, even for minor surgeries, can also significantly complicate the production of any of the surgically produced models. 


Downloadable E-Book

Miniature Swine Book of Normals 

The Miniature Swine Book of Normals features a comprehensive collection of normal pathological and biological data collected on Sinclair’s lineages of miniature swine. Sinclair BioResources is pleased to make this information available to veterinarians, biomedical investigators, preclinical clients and university staff to facilitate research when using our miniature swine models.